Publications
- Publications >40, citation >1400, H-index 18 (Updated Jan 2025)
- (*) indicates corresponding authors.
- Since 2024, the published name has been changed from ‘Li Lin’ to ‘Linley Li Lin’.
Highlighted
Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering
Li Lin*, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, Shuming Nie*, Jian Ye*
Med-X
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14 Aug 2023
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doi:10.1007/s44258-023-00010-2
We report the use of surface-enhanced Raman scattering nanotags embedded in ex-vivo animal tissues for direct and quantitative measurements of light attenuation and spectroscopic detection depth at both the NIR-I and NIR-II spectral windows.
In Vivo Surface‐Enhanced Transmission Raman Spectroscopy under Maximum Permissible Exposure: Toward Photosafe Detection of Deep‐Seated Tumors
Yumin Zhang, Ruoyu Chen, Peng Miao, Li Lin*, Jian Ye*
Small Methods
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26 Dec 2022
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doi:10.1002/smtd.202201334
Non‐Invasive Detection, Precise Localization, and Perioperative Navigation of In Vivo Deep Lesions Using Transmission Raman Spectroscopy
Zongyu Wu, Binge Deng*, Yutong Zhou, Haoqiang Xie, Yumin Zhang, Li Lin*, Jian Ye*
Advanced Science
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20 Jun 2023
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doi:10.1002/advs.202301721
In Vivo Surface-Enhanced Transmission Raman Spectroscopy and Impact of Frozen Biological Tissues on Lesion Depth Prediction
Yutong Zhou, Yumin Zhang, Haoqiang Xie, Zongyu Wu, Bowen Shi, Linley Li Lin*, Jian Ye*
ACS Nano
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16 Dec 2024
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doi:10.1021/acsnano.4c12469
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2025
Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges
Linley Li Lin, Ramon Alvarez-Puebla, Luis M. Liz-Marzán, Matt Trau, Jing Wang, ..., Bin Ren, Shuming Nie, Bing Zhao, Xing Yi Ling, Jian Ye
ACS Applied Materials & Interfaces
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24 Feb 2025
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doi:10.1021/acsami.4c17502
Single-Injection Composite Tracer Achieves Intraoperative Dual-Tracing and Precise Localization of Sentinel Lymph Nodes
Binge Deng, Linley Li Lin*, Yan Wang, Xiangdong Bu, Jin Li, Jingsong Lu, Yaohui Wang*, Yao Chen*, Jian Ye*
ACS Applied Materials & Interfaces
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16 Jan 2025
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doi:10.1021/acsami.4c20139
Raman spectroscopy analysis combined with computed tomography imaging to identify microsatellite instability in gastric cancers
Bowen Shi#, Wenfang Wang#, Shiyan Fang#, Siyi Wu, Lan Zhu, ..., Fuhua Yan, Fei Yuan, Jian Ye*, Huan Zhang*, Linley Li Lin*
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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01 Jan 2025
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doi:10.1016/j.saa.2024.125062
2024
In Vivo Surface-Enhanced Transmission Raman Spectroscopy and Impact of Frozen Biological Tissues on Lesion Depth Prediction
Yutong Zhou, Yumin Zhang, Haoqiang Xie, Zongyu Wu, Bowen Shi, Linley Li Lin*, Jian Ye*
ACS Nano
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16 Dec 2024
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doi:10.1021/acsnano.4c12469
Oppositely-charged silver nanoparticles enable selective SERS molecular enhancement through electrostatic interactions
Yuqing Gu, Siyi Wu, Zhewen Luo, Linley Li Lin*, Jian Ye*
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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01 Dec 2024
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doi:10.1016/j.saa.2024.124852
Multiwavelength Surface-Enhanced Raman Scattering Fingerprints of Human Urine for Cancer Diagnosis
Yuqing Gu, Jiayi Wang, Zhewen Luo, Xingyi Luo, Linley Li Lin, ..., Zehou Su, Yao Lu, Li-Yong Gan, Zhou Chen, Jian Ye
ACS Sensors
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18 Oct 2024
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doi:10.1021/acssensors.4c01873
Raman fiber-optic probe for rapid diagnosis of gastric and esophageal tumors with machine learning analysis or similarity assessments: a comparative study
Shiyan Fang, Pei Xu, Siyi Wu, Zhou Chen, Junqing Yang, ..., Shuchun Li, Jin Sun, Zirui He*, Jian Ye*, Linley Li Lin*
Analytical and Bioanalytical Chemistry
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25 Sep 2024
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doi:10.1007/s00216-024-05545-w
Label-Free Surface-Enhanced Raman Spectroscopy with Machine Learning for the Diagnosis of Thyroid Cancer by Using Fine-Needle Aspiration Liquid Samples
Lili Gao, Siyi Wu, Puwasit Wongwasuratthakul, Zhou Chen, Wei Cai, Qinyu Li, Linley Li Lin
Biosensors
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31 Jul 2024
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doi:10.3390/bios14080372
Sentinel lymph node identification using NIR-II ultrabright Raman nanotags on preclinical models
Binge Deng, Yan Wang, Xiangdong Bu, Jin Li, Jingsong Lu, Linley Li Lin*, Yaohui Wang*, Yao Chen*, Jian Ye*
Biomaterials
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01 Jul 2024
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doi:10.1016/j.biomaterials.2024.122538
NIR‐II Surface‐Enhanced Raman Scattering Nanoprobes in Biomedicine: Current Impact and Future Directions
Binge Deng, Yuqing Zhang, Guangyu Qiu, Jin Li, Linley Li Lin*, Jian Ye*
Small
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07 Jun 2024
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doi:10.1002/smll.202402235
SERSomes for metabolic phenotyping and prostate cancer diagnosis
Xinyuan Bi, Jiayi Wang, Bingsen Xue, Chang He, Fugang Liu, ..., Butang Li, Cheng Jin, Jiahua Pan, Wei Xue, Jian Ye
Cell Reports Medicine
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01 Jun 2024
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doi:10.1016/j.xcrm.2024.101579
Raman spectroscopy for esophageal tumor diagnosis and delineation using machine learning and the portable Raman spectrometer
Junqing Yang , Pei Xu, Siyi Wu, Zhou Chen, Shiyan Fang, ..., Lei Wang, Bin Mo, Fangbao Ding*, Linley Li Lin*, Jian Ye*
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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11 May 2024
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doi:10.1016/j.saa.2024.124461
Recent progress and applications of Raman spectrum denoising algorithms in chemical and biological analyses: A review
Shiyan Fang, Siyi Wu, Zhou Chen, Chang He, Linley Li Lin*, Jian Ye*
TrAC Trends in Analytical Chemistry
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01 Mar 2024
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doi:10.1016/j.trac.2024.117578
Biomimetic-Membrane-Protected Plasmonic Nanostructures as Dual-Modality Contrast Agents for Correlated Surface-Enhanced Raman Scattering and Photoacoustic Detection of Hidden Tumor Lesions
Indrajit Srivastava, Ruiyang Xue, Hsuan-Kai Huang, Ziwen Wang, Jamie Jones, ..., Shensheng Zhao, Kristen Flatt, Viktor Gruev, Yun-Sheng Chen, Shuming Nie
ACS Applied Materials & Interfaces
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07 Feb 2024
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doi:10.1021/acsami.3c18488
2023
Artificial Intelligence for Surface‐Enhanced Raman Spectroscopy
Xinyuan Bi, Li Lin, Zhou Chen*, Jian Ye*
Small Methods
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27 Oct 2023
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doi:10.1002/smtd.202301243
Locating Three-Dimensional Position of Deep-Seated SERS Phantom Lesions in Thick Tissues Using Tomographic Transmission Raman Spectroscopy
Haoqiang Xie, Yumin Zhang, Zongyu Wu, Zhouzhou Bao*, Li Lin*, Jian Ye*
ACS Applied Materials & Interfaces
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13 Sep 2023
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doi:10.1021/acsami.3c07792
Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering
Li Lin*, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, Shuming Nie*, Jian Ye*
Med-X
·
14 Aug 2023
·
doi:10.1007/s44258-023-00010-2
We report the use of surface-enhanced Raman scattering nanotags embedded in ex-vivo animal tissues for direct and quantitative measurements of light attenuation and spectroscopic detection depth at both the NIR-I and NIR-II spectral windows.
Non‐Invasive Detection, Precise Localization, and Perioperative Navigation of In Vivo Deep Lesions Using Transmission Raman Spectroscopy
Zongyu Wu, Binge Deng*, Yutong Zhou, Haoqiang Xie, Yumin Zhang, Li Lin*, Jian Ye*
Advanced Science
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20 Jun 2023
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doi:10.1002/advs.202301721
A rapid and universal method for depth estimation of lesions in heterogeneous tissues via photosafe ratiometric transmission Raman spectroscopy
Yumin Zhang, Li Lin*, Jian Ye*
VIEW
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20 Apr 2023
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doi:10.1002/viw.20230022
Euclidean distance-based Raman spectroscopy (EDRS) for the prognosis analysis of gastric cancer: A solution to tumor heterogeneity
Wenfang Wang, Bowen Shi, Chang He, Siyi Wu, Lan Zhu, Jiang Jiang, Lingyun Wang, Li Lin*, Jian Ye*, Huan Zhang*
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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01 Mar 2023
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doi:10.1016/j.saa.2022.122163
Surface-enhanced Raman scattering (SERS) nanoparticles for biodiagnostics, bioimaging, and spectroscopy-guided cancer surgery
Li Lin, Ruiyang Xue, Shuming Nie
Encyclopedia of Nanomaterials
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01 Jan 2023
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doi:10.1016/b978-0-12-822425-0.00111-1
2022
In Vivo Surface‐Enhanced Transmission Raman Spectroscopy under Maximum Permissible Exposure: Toward Photosafe Detection of Deep‐Seated Tumors
Yumin Zhang, Ruoyu Chen, Peng Miao, Li Lin*, Jian Ye*
Small Methods
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26 Dec 2022
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doi:10.1002/smtd.202201334
Resonant Strategy in Designing NIR-II SERS Nanotags: A Quantitative Study
Haoqi He, Shuo Zhu, Yumin Zhang, Jian Ye*, Li Lin*
The Journal of Physical Chemistry C
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22 Jul 2022
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doi:10.1021/acs.jpcc.2c02512
Raman-Guided Bronchoscopy: Feasibility and Detection Depth Studies Using Ex Vivo Lung Tissues and SERS Nanoparticle Tags
Zongyu Wu, Ziwen Wang, Haoqiang Xie, Yiming Wang, Haoqi He, Shuming Nie, Jian Ye, Li Lin*
Photonics
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17 Jun 2022
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doi:10.3390/photonics9060429
Surface-Enhanced Raman Scattering Bioimaging with an Ultrahigh Signal-to-Background Ratio under Ambient Light
Shuo Zhu, Binge Deng, Fugang Liu, Jin Li, Li Lin, Jian Ye*
ACS Applied Materials & Interfaces
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14 Feb 2022
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doi:10.1021/acsami.2c01063
Human metabolite detection by surface-enhanced Raman spectroscopy
Yao Lu, Li Lin*, Jian Ye*
Materials Today Bio
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01 Jan 2022
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doi:10.1016/j.mtbio.2022.100205
2021
Silver nanocubes-based bimetallic core-shell surface-enhanced Raman scattering nanoprobes for cell imaging
Jiao Peng, Li Lin, Jian Ye
2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO)
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02 Aug 2021
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doi:10.1109/3m-nano49087.2021.9599773
Probing electron transport in plasmonic molecular junctions with two-photon luminescence spectroscopy
Qiang Zhang, Danjun Liu, Qun Ren, Nicolae C. Panoiu, Li Lin, Jian Ye, Yang Huang, Shao-Ding Liu, Chi Wah Leung, Dangyuan Lei
Nanophotonics
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09 Jun 2021
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doi:10.1515/nanoph-2021-0116
Surface-enhanced Raman scattering nanotags for bioimaging
Li Lin, Xinyuan Bi, Yuqing Gu, Fu Wang, Jian Ye*
Journal of Applied Physics
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17 May 2021
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doi:10.1063/5.0047578
Optical penetration of surface-enhanced micro-scale spatial offset Raman spectroscopy in turbid gel and biological tissue
Yumin Zhang#, <Li Lin#, Jing He, Jian Ye*
Journal of Innovative Optical Health Sciences
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22 Feb 2021
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doi:10.1142/S1793545821410017
Atomic Insights into the Evolution of Three-Dimensional Molecular Junctions in Plasmonic Core–Shell Nanoparticles
Li Lin, Weiming Ji, Lu-Wen Zhang*, Jian Ye*
The Journal of Physical Chemistry C
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15 Jan 2021
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doi:10.1021/acs.jpcc.0c09552
2020
Gap-enhanced Raman tags for physically unclonable anticounterfeiting labels
Yuqing Gu, Chang He, Yuqing Zhang, Li Lin, Benjamin David Thackray, Jian Ye
Nature Communications
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24 Jan 2020
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doi:10.1038/s41467-019-14070-9
Gap-enhanced Raman tags: fabrication, optical properties, and theranostic applications
Nikolai G. Khlebtsov, Li Lin, Boris N. Khlebtsov, Jian Ye
Theranostics
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01 Jan 2020
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doi:10.7150/thno.39968
2019
Sub-100 nm multi-shell bimetallic gap-enhanced Raman tags
Zhixiang Ye, Li Lin, Ziyang Tan, Yu-Jia Zeng, Shuangchen Ruan, Jian Ye
Applied Surface Science
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01 Sep 2019
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doi:10.1016/j.apsusc.2019.05.200
2018
Surface‐Enhanced Raman Nanoprobes with Embedded Standards for Quantitative Cholesterol Detection
Xin Jiang, Ziyang Tan, Li Lin, Jing He, Chang He, Benjamin D. Thackray, Yuqing Zhang, Jian Ye
Small Methods
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23 Aug 2018
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doi:10.1002/smtd.201800182
Electron Transport Across Plasmonic Molecular Nanogaps Interrogated with Surface-Enhanced Raman Scattering
Li Lin, Qiang Zhang, Xiyao Li, Meng Qiu, Xin Jiang, Wei Jin, Hongchen Gu, Dang Yuan Lei, Jian Ye
ACS Nano
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20 Jun 2018
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doi:10.1021/acsnano.7b08224
2017
Ultraphotostable Mesoporous Silica-Coated Gap-Enhanced Raman Tags (GERTs) for High-Speed Bioimaging
Yuqing Zhang, Yuanyuan Qiu, Li Lin, Hongchen Gu, Zeyu Xiao, Jian Ye
ACS Applied Materials & Interfaces
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24 Jan 2017
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doi:10.1021/acsami.6b15170
Quantifying the reflective index of nanometer-thick thiolated molecular layers on nanoparticles
Li Lin, Zhonghui Liu, Xiyao Li, Hongchen Gu, Jian Ye
Nanoscale
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01 Jan 2017
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doi:10.1039/c6nr08501f
2015
Nanooptics of Plasmonic Nanomatryoshkas: Shrinking the Size of a Core–Shell Junction to Subnanometer
Li Lin, Mario Zapata, Min Xiong, Zhonghui Liu, Shanshan Wang, ..., Andrei G. Borisov, Hongchen Gu, Peter Nordlander, Javier Aizpurua, Jian Ye
Nano Letters
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21 Sep 2015
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doi:10.1021/acs.nanolett.5b02931
Plasmonic multi-shell nanomatryoshka particles as highly tunable SERS tags with built-in reporters
Li Lin, Hongchen Gu, Jian Ye
Chemical Communications
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01 Jan 2015
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doi:10.1039/c5cc06599b