Publications

Publications >30, citation >1200, H-index 15 (Updated Sept 2024)
(*) indicates corresponding authors.
Since 2024, the published name has been changed from ‘Li Lin’ to ‘Linley Li Lin’.

Highlighted

Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering

Li Lin*, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, Shuming Nie*, Jian Ye*

Med-X · 14 Aug 2023 · doi:10.1007/s44258-023-00010-2

We report the use of surface-enhanced Raman scattering nanotags embedded in ex-vivo animal tissues for direct and quantitative measurements of light attenuation and spectroscopic detection depth at both the NIR-I and NIR-II spectral windows.

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2025

Raman spectroscopy analysis combined with computed tomography imaging to identify microsatellite instability in gastric cancers

Bowen Shi#, Wenfang Wang#, Shiyan Fang#, Siyi Wu, Lan Zhu, ..., Fuhua Yan, Fei Yuan, Jian Ye*, Huan Zhang*, Linley Li Lin*

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 01 Jan 2025 · doi:10.1016/j.saa.2024.125062

Raman diagnosis Gastric tumor EDRS

2024

Oppositely-charged silver nanoparticles enable selective SERS molecular enhancement through electrostatic interactions

Yuqing Gu, Siyi Wu, Zhewen Luo, Linley Li Lin*, Jian Ye*

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 01 Dec 2024 · doi:10.1016/j.saa.2024.124852

SERS Metabolite detection Liquid biopsy

Label-Free Surface-Enhanced Raman Spectroscopy with Machine Learning for the Diagnosis of Thyroid Cancer by Using Fine-Needle Aspiration Liquid Samples

Lili Gao, Siyi Wu, Puwasit Wongwasuratthakul, Zhou Chen, Wei Cai, Qinyu Li, Linley Li Lin

Biosensors · 31 Jul 2024 · doi:10.3390/bios14080372

Raman diagnosis Thyroid tumor Liquid biopsy

Sentinel lymph node identification using NIR-II ultrabright Raman nanotags on preclinical models

Binge Deng, Yan Wang, Xiangdong Bu, Jin Li, Jingsong Lu, Linley Li Lin*, Yaohui Wang*, Yao Chen*, Jian Ye*

Biomaterials · 01 Jul 2024 · doi:10.1016/j.biomaterials.2024.122538

NIR-II GERTs

NIR‐II Surface‐Enhanced Raman Scattering Nanoprobes in Biomedicine: Current Impact and Future Directions

Binge Deng, Yuqing Zhang, Guangyu Qiu, Jin Li, Linley Li Lin*, Jian Ye*

Small · 07 Jun 2024 · doi:10.1002/smll.202402235

NIR-II SERS

SERSomes for metabolic phenotyping and prostate cancer diagnosis

Xinyuan Bi, Jiayi Wang, Bingsen Xue, Chang He, Fugang Liu, ..., Butang Li, Cheng Jin, Jiahua Pan, Wei Xue, Jian Ye

Cell Reports Medicine · 01 Jun 2024 · doi:10.1016/j.xcrm.2024.101579

Raman spectroscopy for esophageal tumor diagnosis and delineation using machine learning and the portable Raman spectrometer

Junqing Yang , Pei Xu, Siyi Wu, Zhou Chen, Shiyan Fang, ..., Lei Wang, Bin Mo, Fangbao Ding*, Linley Li Lin*, Jian Ye*

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 11 May 2024 · doi:10.1016/j.saa.2024.124461

Raman disnosis Esophageal tumor

Recent progress and applications of Raman spectrum denoising algorithms in chemical and biological analyses: A review

Shiyan Fang, Siyi Wu, Zhou Chen, Chang He, Linley Li Lin*, Jian Ye*

TrAC Trends in Analytical Chemistry · 01 Mar 2024 · doi:10.1016/j.trac.2024.117578

AI Spectral denoising Raman

Biomimetic-Membrane-Protected Plasmonic Nanostructures as Dual-Modality Contrast Agents for Correlated Surface-Enhanced Raman Scattering and Photoacoustic Detection of Hidden Tumor Lesions

Indrajit Srivastava, Ruiyang Xue, Hsuan-Kai Huang, Ziwen Wang, Jamie Jones, ..., Shensheng Zhao, Kristen Flatt, Viktor Gruev, Yun-Sheng Chen, Shuming Nie

ACS Applied Materials & Interfaces · 07 Feb 2024 · doi:10.1021/acsami.3c18488

2023

Artificial Intelligence for Surface‐Enhanced Raman Spectroscopy

Xinyuan Bi, Li Lin, Zhou Chen*, Jian Ye*

Small Methods · 27 Oct 2023 · doi:10.1002/smtd.202301243

SERS AI

Locating Three-Dimensional Position of Deep-Seated SERS Phantom Lesions in Thick Tissues Using Tomographic Transmission Raman Spectroscopy

Haoqiang Xie, Yumin Zhang, Zongyu Wu, Zhouzhou Bao*, Li Lin*, Jian Ye*

ACS Applied Materials & Interfaces · 13 Sep 2023 · doi:10.1021/acsami.3c07792

Transmission Raman Spectroscopy Tomography GERTs

Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering

Li Lin*, Haoqi He, Ruiyang Xue, Yumin Zhang, Ziwen Wang, Shuming Nie*, Jian Ye*

Med-X · 14 Aug 2023 · doi:10.1007/s44258-023-00010-2

SERS Detection depth assessment Second near-infrared window NIR-II GERTs

Non‐Invasive Detection, Precise Localization, and Perioperative Navigation of In Vivo Deep Lesions Using Transmission Raman Spectroscopy

Zongyu Wu, Binge Deng*, Yutong Zhou, Haoqiang Xie, Yumin Zhang, Li Lin*, Jian Ye*

Advanced Science · 20 Jun 2023 · doi:10.1002/advs.202301721

Transmission Raman spectroscopy Noninvasive in vivo detection

A rapid and universal method for depth estimation of lesions in heterogeneous tissues via photosafe ratiometric transmission Raman spectroscopy

Yumin Zhang, Li Lin*, Jian Ye*

VIEW · 20 Apr 2023 · doi:10.1002/viw.20230022

Transmission Raman spectroscopy Depth estimation

Euclidean distance-based Raman spectroscopy (EDRS) for the prognosis analysis of gastric cancer: A solution to tumor heterogeneity

Wenfang Wang, Bowen Shi, Chang He, Siyi Wu, Lan Zhu, Jiang Jiang, Lingyun Wang, Li Lin*, Jian Ye*, Huan Zhang*

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy · 01 Mar 2023 · doi:10.1016/j.saa.2022.122163

Euclidean distance Raman spectroscopy EDRS Stomach cancer prognosis

Surface-enhanced Raman scattering (SERS) nanoparticles for biodiagnostics, bioimaging, and spectroscopy-guided cancer surgery

Li Lin, Ruiyang Xue, Shuming Nie

Encyclopedia of Nanomaterials · 01 Jan 2023 · doi:10.1016/b978-0-12-822425-0.00111-1

Book chapter SERS Nanoparticle Encyclopedia of Nanomaterials

2022

In Vivo Surface‐Enhanced Transmission Raman Spectroscopy under Maximum Permissible Exposure: Toward Photosafe Detection of Deep‐Seated Tumors

Yumin Zhang, Ruoyu Chen, Peng Miao, Li Lin*, Jian Ye*

Small Methods · 26 Dec 2022 · doi:10.1002/smtd.202201334

Transmission Raman spectroscopy Ultrahigh detection depth in biological tissues

Resonant Strategy in Designing NIR-II SERS Nanotags: A Quantitative Study

Haoqi He, Shuo Zhu, Yumin Zhang, Jian Ye*, Li Lin*

The Journal of Physical Chemistry C · 22 Jul 2022 · doi:10.1021/acs.jpcc.2c02512

Second near-infrared window NIR-II SERS tag Au nanorod

Raman-Guided Bronchoscopy: Feasibility and Detection Depth Studies Using Ex Vivo Lung Tissues and SERS Nanoparticle Tags

Zongyu Wu, Ziwen Wang, Haoqiang Xie, Yiming Wang, Haoqi He, Shuming Nie, Jian Ye, Li Lin*

Photonics · 17 Jun 2022 · doi:10.3390/photonics9060429

Bronchoscopy Lung Tissue GERTs

Surface-Enhanced Raman Scattering Bioimaging with an Ultrahigh Signal-to-Background Ratio under Ambient Light

Shuo Zhu, Binge Deng, Fugang Liu, Jin Li, Li Lin, Jian Ye*

ACS Applied Materials & Interfaces · 14 Feb 2022 · doi:10.1021/acsami.2c01063

Au nanorod SERS

Human metabolite detection by surface-enhanced Raman spectroscopy

Yao Lu, Li Lin*, Jian Ye*

Materials Today Bio · 01 Jan 2022 · doi:10.1016/j.mtbio.2022.100205

SERS Metabolite detection

2021

Silver nanocubes-based bimetallic core-shell surface-enhanced Raman scattering nanoprobes for cell imaging

Jiao Peng, Li Lin, Jian Ye

2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) · 02 Aug 2021 · doi:10.1109/3m-nano49087.2021.9599773

Probing electron transport in plasmonic molecular junctions with two-photon luminescence spectroscopy

Qiang Zhang, Danjun Liu, Qun Ren, Nicolae C. Panoiu, Li Lin, Jian Ye, Yang Huang, Shao-Ding Liu, Chi Wah Leung, Dangyuan Lei

Nanophotonics · 09 Jun 2021 · doi:10.1515/nanoph-2021-0116

Surface-enhanced Raman scattering nanotags for bioimaging

Li Lin, Xinyuan Bi, Yuqing Gu, Fu Wang, Jian Ye*

Journal of Applied Physics · 17 May 2021 · doi:10.1063/5.0047578

review SERS