BIOGRAPHY

Dr. Linley Li Lin is currently an associate professor at Shanghai Jiao Tong University (SJTU). She received her B.S. and Ph.D. degrees from SJTU and conducted her postdoctoral fellow at the University of Illinois at Urbana-Champaign and SJTU. Her academic research is primarily in the area of plasmonic nanostructures, nanomedicine, and image-guided surgery. During her PhD and Postdoctoral research, she was one of the principal researchers of GERTs - a novel SERS nanotag with ultra-high sensitivity, uniformity, and photostability. Her current research interests include deep Raman techniques, surface-enhanced Raman scattering bioimaging, and Raman spectroscopic platform to study biomaterial interfaces. She has developed in vivo transmission Raman spectroscopy techniques for deep Raman imaging and three-dimensional tomography. Her team’s pioneering works include the Deep Raman optical detection through biological tissues, and for the first-time the non-invasive localization of in vivo deep-seated lesions on live big animal models using deep Raman spectroscopy. Dr. Lin has received a number of awards, including the Shanghai Chenguang Young Scholar Program (2021) and the Best Paper Award at the IMCO International Conference (2019).

EDUCATION

• Ph.D., Biomedical Engineering, Shanghai Jiao Tong University, 2013-2018, Thesis Title: The Synthesis and Biomedical Applications of Gap Enhanced Raman Tags (GERTs)
• B.S., Biomedical Engineering, Shanghai Jiao Tong University, China, 2009-2013
• Visiting Student, Department of Biomedical Engineering, University of Minnesota, U.S., 2012 Summer

PROFESSIONAL EMPLOYMENT

• Associate Professor, School of Biomedical Engineering, Shanghai Jiao Tong University, 2025-now
• Assistant Professor, School of Biomedical Engineering, Shanghai Jiao Tong University, 2021-2024
• Visiting scholar and postdoctoral Fellow, Department of Bioengineering, University of Illinois at Urbana-Champaign (Advisor: Prof. Shuming Nie), 2018-2020
• Postdoctoral Fellow, School of Biomedical Engineering, Shanghai Jiao Tong University, 2018-2021

HONORS AND AWARDS

• 2025 SJTU Youth Post Expert (交大青年岗位能手）
• 2023 Wiley (China) Open Science Excellent Author
• 2023 SJTU Teaching Award, Second-Tier (校级教学成果奖二等奖)
• 2022 Shanghai Education Municipal Chen-Guang Young Scholar Program (上海市晨光学者)
• 2021 Best Paper Award Nomination, IEEE 3M-Nano Conference
• 2021 Best Cover Article Award, JIOHS journal
• 2019 Best Paper Award, The 9th International Multidisciplinary Conference on Optofluidics
• 2018 Shanghai Excellent Graduates
• 2017 Academic Rising Star in Shanghai Jiao Tong University (Top 10 students per year)
• 2017 Best Poster Award, 2017 International Conference on SERS
  

  Advisor Awards

• 2024 China International College Students Innovation Competition, Gold Medal (Student: Zongyu WU, Haoqiang XIE, Yang LUO, Han GU,互联网+国际大学生创新创业竞赛全国金奖)
• 2024 Shanghai International College Students Innovation Competition, Champion (Student: Zongyu WU, Haoqiang XIE, Yang LUO, Han GU, 互联网+国际大学生创新创业竞赛上海赛冠军)
• 2023 National College Student Competition Challenge Cup Advisor Award (Student: Zongyu WU, Haoqiang XIE, Mingyuan XIA, Yang LUO, 挑战杯全国大学生课外科创竞赛)
• 2023 The National Training Program of Innovation and Entrepreneurship for Undergraduates Advisor Award (Student: Haoqiang XIE, 国家级大学生创新创业训练项目)
• 2023 Shanghai College Student Competition Challenge Cup Advisor Award (上海市挑战杯大学生课外科创竞赛)
• 2022 National College Student Biomedical Engineering Innovation Design Competition Advisor Award (全国大学生生物医学工程创新设计竞赛).

PUBLICATIONS

Since 2024, the published name has been changed from ‘Li Lin’ to ‘Linley Li Lin’. So far, Dr. Lin has published over 50 journal papers with the citation of over 1900. See publication list.

Featured Publications

Book Chapters

• Yuqing Zhang, Han Gu, Zongyu Wu, Jian Ye, Linley Li Lin*. “Nano-engineering for gap-enhanced Raman tags (GERTs) and related plasmonic applications”, In: Nano-Engineering at Functional Interfaces, Elsevier, 2025, Pages 75-91. (https://doi.org/10.1016/B978-0-443-21691-6.00005-6)
  
• Li Lin, Ruiyang Xue, Shuming Nie. “Surface-enhanced Raman scattering (SERS) nanoparticles for biodiagnostics, bioimaging, and spectroscopy-guided cancer surgery”, In: Reference Module in Materials Science and Materials Engineering, Elsevier, 2022, pp340-355. (https://dio.org/10.1016/B978-0-12-822425-0.00111-1)
  
• Li Lin, Jian Ye, “Spontaneous Raman and Surface-Enhanced Raman Scattering Bioimaging”, In: Wei X., Gu B. (eds) Optical imaging in Human Disease and Biological Research. Advances in Experimental Medicine and Biology, vol 3233. Springer, Singapore, 2021, pp177-195.
  

  Approved patents (to be updated)

• A method to quantify the reflective index of nanometer-thick molecular layers, China Patent 2016
• The synthesis of a multi-layered core-shell SERS probe, China Patent 2015
• A method for locating the depth of lesions in heterogeneous tissues, China Patent 2023
• A method for measuring differences in effective attenuation coefficients of photons at different wavelengths in biological tissues, China Patent 2023
• A method based on transmitted Raman spectroscopy and two-step scanning for the localization of Raman imaging contrast agents, China Patent 2023
• A deep detection system, method and application based on a large-spot spatially-offset Raman spectroscopy probe, China Patent 2024

SERVICE

• Early Career Editorial Board, ACS Applied Materials & Interfaces (2025-2027)
  
• Early Career Editorial Board, Exploration (2024-2025)
  
• Journal Reviewer (Chemical Society Reviews, Analytical Chemistry, ACS Omega, ACS Applied Electronic Materials, Nature Communications, Journal of Materials Chemistry B, Environmental Science & Technology, Biosensors and Bioelectronics, IEEE Transactions on Biomedical Engineering, Optics and Lasers in Engineering, Applied Materials Today, Chemical Engineering Journal, Nanophotonics, Biosensors, Bioengineering and Translational Medicine, Photonics, Lab Investigations, etc.)

GRANTS

• National Key Research and Development Program of China, 2M, sub-project PI, 2024-2027.
• Shanghai Jiao Tong University Medicine-Engineering Program, co-PI, 2024-2026, AI-assisted diagnosis and delineation of esophageal cancer lesion using the portable Raman system
• National Science Foundation of China (NSFC), PI, 2024-2027, Deep Raman techniques for the non-invasive photosafe detection and depth estimation of in vivo lesions
• Shanghai Science and Technology Research Program, 1M, sub-project PI, 2021-2023, Raman fiber-optics and micromedical robot based spectroscopic tumor biopsy
• Shanghai Municipal Chen-Guang Program, PI, 2022-2023, Transmission Raman spectroscopy for the non-invasive detection of in vivo lesions
• Shanghai Jiao Tong University Medicine-Engineering Program, co-PI, 2022-2024, Rapid diagnosis of gastric cancer based on Raman fiber-optics system and machine learning algorithm
• National Science Foundation of China (NSFC), PI, 2019-2022, Enhanced Raman Tags in the Second Near-Infrared Window and Their Tissue Penetration Depth Study
• Start-up funding support, PI, SJTU

INVITED TALKS

• In Vivo SEDRS: Non-invasive Detection and Image-Guided Surgery of Deep-Seated Lesions, AMI Conference, July 2025, Singapore. (Session Chair)
• In Vivo Deep Raman Spectroscopy for Tomography and Image-Guided Surgery, 2nd MED-X International conferences, Dec 2024, Shanghai.
• Non-Invasive Raman Optical Imaging on Small Animal Models, Instrumental Website Online Webinar, May 2024.
• Deep Raman Spectroscopy for Non-invasive In Vivo Optical Imaging, NELM conference, April 2024, Hangzhou, China.
• Surface-Enhanced Deep Raman Spectroscopy: Advancements and Challenges, 3rd NCRBA conference, March 2024, Shanghai, China.
• In Vivo Surface-Enhanced Transmission Raman Spectroscopy: Advancing Toward Photosafe Non-invasive Detection of Deep-Seated Lesions, SciX, October 2023, Sparks, Nevada.
• Surface-Enhanced Transmission Raman Spectroscopy: Toward Photosafe Non-invasive Diagnosis, Photonix Conference, May 2023, Hangzhou, China.
• In Vivo Surface-Enhanced Transmission Raman Spectroscopy for Photosafe Non-invasive Diagnosis, Instrumental Website Online Webinar, June 2023, Online.
• Quantitative Direct Assessment of Raman Spectroscopic Tissue Penetration Depth in the NIR Window, PIBM Conference, December 2021, Haikou, Hainan, China.
• Tissue Optical Properties and Tissue Penetration: Implications for Surgical Navigation and Guidance, BIOE498/598 class, University of Illinois at Urbana-Champaign, September 2020.
• Biomedical Applications Based on Surface-Enhanced Raman Scattering, Online Webinar, Horiba Inc., February 2020.

TEACHING

• BME9001, Frontiers of Biomedical Engineering(医学工程前沿进展), Fall semester, From 2023
• GE7002, Ethics and Academic Integrity of Medicine and Engineering(医工交叉的学术伦理与规范), Fall semester, From 2023
• BME7006, Academic Integrity and Research Ethics (English Class)(学术伦理与科研规范-全英文班), Fall semester, From 2022
• BME8201, Spectroscopic Nanomaterials in Biomedical Application(纳米光学材料的生物医学应用), Spring semester, From 2022